I am glad you took your cat to the veterinarian and that his physical exam was normal. Refusing to eat and these kinds of changes are not normal. While his physical exam may have been normal, I would strongly recommend lab work if it was not done. Many times a cat may have a great check-up but lab values that are out of whack signifying kidney or liver disease. If lab work is all normal, I would consider gastrointestinal disease. Many times cats can have normal lab work but pretty significant inflammation of their intestines (inflammatory bowel disease) or pancreas. This is extremely common. It can be very serious when a cat is not eating, especially if they are overweight. This is due to the possibility of fatty liver disease. I would encourage you to return to your veterinarian and intervene. Your cat needs further diagnostics or medical intervention before things get worse. Good luck!
Source: http://www.catchow.com
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